Beyond Hyaluronic Acid: Why Polynucleotides (Salmon DNA) Are the Future of Skin Regeneration
For the last decade, Hyaluronic Acid (HA) fillers have dominated the aesthetic industry. They are excellent at what they do: attracting water and adding immediate volume.
But the conversation in elite aesthetic circles is shifting. We are moving from an era of "filling" to an era of "regeneration."

At Uplifted Aesthetics in Redondo Beach, we believe the ultimate goal isn’t just to mask aging—it’s to reverse it at a cellular level. This is why we are among the first in the South Bay to introduce Polynucleotides, often buzzed about as the "Salmon DNA Facial."
This isn't just another serum; it's biological architecture for your skin.
What are Polynucleotides (PDRN)? Polynucleotides are highly purified DNA fragments derived from salmon or trout sperm. Because salmon DNA is incredibly similar to human DNA, it is highly biocompatible.
What do they do? Unlike fillers that just sit in the skin, polynucleotides act as
biostimulators. They signal your cells to repair damaged tissues, reduce inflammation, and grow new blood vessels, leading to thicker, healthier skin over time.
The Analogy: Renovation vs. Furniture
To understand the difference between traditional treatments and this new regenerative approach, think of your face as a house.
- Hyaluronic Acid Fillers are like buying new furniture. They fill empty spaces and make the room look immediately better, but they don't change the structure of the house.
- Polynucleotides are like repairing the damaged drywall, fixing the foundation, and upgrading the plumbing.
We aren't just decorating; we are renovating the skin's infrastructure.
The Science: How PDRN Works
Polynucleotides work on a cellular level to kickstart your skin’s natural healing abilities. They are particularly powerful because they do three things simultaneously:
- Fibroblast Stimulation: They wake up the cells responsible for creating collagen and elastin.
- Anti-Inflammatory Action: They calm angry, inflamed skin (excellent for rosacea or sensitive skin).
- Angiogenesis: They promote the formation of new capillaries, improving blood flow and oxygenation to the skin for that coveted "glow."
The Uplifted Difference: LumEnvy & GlowPin
Hula Castellon, FNP, is selective about the technologies introduced to the clinic. We utilize LúmEnvy, a premium line of polynucleotides tailored for different skin concerns.
Our delivery method for LúmEnvy is The GlowPin.
The GlowPin is a multi-needle nano-delivery system. It allows us to stamp the regenerative serum directly into the dermis with virtually no pain and zero downtime. It’s not a traditional injection; it’s an advanced infusion.
Who Is The Ideal Candidate?
Polynucleotides are unique because they treat areas that traditional fillers often fail. You are a perfect candidate if you struggle with:
- Dark Under-Eye Circles: Fillers here can sometimes look puffy or cause a blue tint (Tyndall effect). Polynucleotides actually thicken the thin skin and improve circulation to reduce darkness naturally.
- Crepey "Textured" Skin: Excellent for fine lines on the neck (tech neck), décolleté, and back of hands.
- Acne Scarring & Rosacea: The potent anti-inflammatory properties help heal compromised skin barriers.
- The "Over-Filled" Patient: If you currently have filler but your skin quality looks dull, this is the perfect complementary treatment to restore surface health.
Experience the Future of Aesthetics
Regenerative medicine is not a trend; it is the future of anti-aging. Be among the first in Redondo Beach to experience the healing power of polynucleotides.









